Alzheimer’s Genetic Risk; Underreported Dementia; Exercise or Nap After Sleep Loss?

A new APOE-independent multi-ancestry polygenic risk score for Alzheimer’s disease was associated with cognitive decline and neuropathological hallmarks in a study of diverse populations. (Nature Genetics)

Diabetes-related cortical thinning in cognitively unimpaired older adults followed a regional pattern independent of Alzheimer’s and cerebrovascular pathology, imaging data showed. (Brain)

Decisions about using amyloid-targeting therapies in Alzheimer’s patients with suspected co-pathologies require careful clinical judgment and shared decision-making, researchers said. (JAMA Neurology)

The oral Bruton’s tyrosine kinase (BTK) inhibitor remibrutinib (Rhapsido), a drug approved for chronic spontaneous urticaria, reduced relapse rates compared with teriflunomide (Aubagio) in two relapsing multiple sclerosis phase III trials, Novartis announced.

Older adults who experienced food insecurity in midlife and late life had higher risks of probable dementia than those who remained food secure, a large prospective cohort study showed. (American Journal of Clinical Nutrition)

Health and Retirement Study data showed that 67% of participants with a claims-based dementia diagnosis did not self-report their diagnosis, far exceeding underreporting rates for other conditions. (JAMA Network Open)

Only 31% of former National Football League players with clinician-adjudicated dementia had neurodegenerative disease listed as their underlying cause of death in a study of brain donors. (JAMA Network Open)

Chronic exposure to adverse policing, including persistent encounters with punitive surveillance and law enforcement, may influence the relationship between depressive symptoms and cognition, a study of older Black adults in the U.S. suggested. (Alzheimer’s & Dementia)

Researchers unveiled the largest map to date of proteins linked to autism. (Science)

Electroencephalography (EEG) data identified a mechanism that may tell the brain which daily experiences to save as long-term memories during sleep. (PLOS Biology)

Both exercise and napping protected episodic memory after sleep loss through distinct brain mechanisms, a study of young healthy adults showed. (PNAS)