Dementia Cases Rising; Tylenol’s Effect on Brain Organoids; Early-Onset Alzheimer’s
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An estimated 11.4 million new dementia cases occurred worldwide in 2023, and the number is projected to jump to 24.7 million new cases a year by 2050, a meta-analysis of 22 cohort studies showed. (JAMA Neurology)
Investigational solengepras used in conjunction with levodopa met its primary endpoint in the phase III ARISE trial of Parkinson’s disease, Cerevance said.
Higher physical activity levels were associated with slower cognitive and motor progression among people with Parkinson’s in a longitudinal study. (Neurology)
Exposing cortical organoids to acetaminophen (Tylenol) at a stage corresponding to late first-trimester human development produced minimal molecular and functional effects, an experiment showed. (Molecular Psychiatry)
A preprint paper reported that the number of high-confidence autism-linked genes increased to 253, while two separate analyses showed how genetic variants contribute to susceptibility. (The Transmitter)
Plasma phosphorylated tau 217 percentage varied across race and ethnicity groups and APOE4 status in a cross-sectional study of more than 15,000 people with asymptomatic Alzheimer’s disease. (JAMA Neurology)
Early-onset Alzheimer’s disease was preceded by a distinct profile of comorbidities up to 15 years before diagnosis, a population-based case-control study in Finland found. (Alzheimer’s & Dementia)
Generic dimethyl fumarate, fingolimod, and teriflunomide showed greater variability in multiple sclerosis protein biomarkers compared with their brand-name counterparts. (Clinical Immunology)
Nearly one-third of women with epilepsy taking certain hormonal contraceptives were co-prescribed antiseizure medications that may have reduced contraceptive effectiveness, Medicaid claims data showed. (Neurology)
The NCAA and Department of Defense’s CARE Consortium, a major concussion research alliance, is approaching the end of its 5-year cycle, and the NCAA’s future financial support seems uncertain. (Sportico)
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