Accelerated Aging and Colon Cancer; Hepatitis B From a Cat? Food Triggers in IBD
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In a large Korean cohort, accelerated biological aging was associated with a 93% increased risk of early-onset colorectal adenocarcinoma and a 132% higher risk of early-onset colon adenocarcinoma specifically. (Clinical Gastroenterology and Hepatology)
An algorithm using routinely collected clinical parameters could offer insight into pancreatic cancer risk in type 2 diabetes patients, a study from China suggested. (Gut)
Experts in Clinical Gastroenterology and Hepatology reviewed the diagnosis and management of acid-related disorders, including gastroesophageal reflux disease, peptic ulcer disease, and more.
Anorectal biofeedback therapy and dextranomer-hyaluronate injections showed similar efficacy in a randomized study of refractory fecal incontinence. (Clinical Gastroenterology and Hepatology)
Researchers suggested there’s a marginal risk of hepatitis B virus transmission from domestic cats to humans. (Hepatology)
In a phase II trial of chronic hepatitis C, an 8-week course of investigational bemnifosbuvir and ruzasvir led to sustained virologic response in 90% of patients at 12 weeks. (Hepatology)
The American College of Gastroenterology issued new guidelines on preventive care in cirrhosis. (American Journal of Gastroenterology)
Renin-angiotensin system inhibitors and calcium channel blockers may be liver protective for hypertensive patients with metabolic dysfunction-associated steatotic liver disease. (Clinical Gastroenterology and Hepatology)
Resmetirom’s (Rezdiffra) efficacy in metabolic dysfunction-associated steatohepatitis (MASH) appeared to be independent of common MASH risk genotypes, according to an analysis of the drug’s pivotal trial. (Journal of Hepatology)
Liver transplant for patients with acute-on-chronic liver failure was associated with markedly lower 1-year mortality in a global study. (Journal of Hepatology)
Sex differences in hepatocellular carcinoma mortality. (JAMA Network Open)
Why do inflammatory bowel disease (IBD) patients experience symptoms from foods they previously tolerated? Researchers uncovered clues. (Gastroenterology)
Mount Sinai announced NIH funding for a study to investigate whether per- and polyfluoroalkyl substances — so-called forever chemicals — play a role in IBD development.
In a nationwide cohort study, early surgical intervention with colectomy in ulcerative colitis was linked with lower cardiometabolic disease risks later on. (American Journal of Gastroenterology)
A network meta-analysis of advanced therapies as induction for ulcerative colitis backed upadacitinib (Rinvoq) for efficacy and anti-p19 biologics in terms of safety. (Clinical Gastroenterology and Hepatology)
Meanwhile, a retrospective study comparing JAK inhibitors for acute severe ulcerative colitis found a higher rate of colectomy at 52 weeks with Tofacitinib (Xeljanz) than with upadacitinib (42.5% vs 23.4%). (Clinical Gastroenterology and Hepatology)
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