Iron, Selenium, and Dementia; Epilepsy and Education; Brain Death Conversations

Lower plasma iron and higher plasma selenium levels were each tied to a greater risk of dementia, data from National Alzheimer’s Coordinating Center participants showed. (Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring)

Alcohol use disorder was associated with a higher risk of developing the behavioral variant of Alzheimer’s disease, a cross-sectional study in Portugal suggested. (Neurology Open Access)

A House Oversight Committee investigation found that the Navy largely ignored observations of potential brain injuries in its pilots, the New York Times reported.

Childhood-onset epilepsy was linked with lower primary school completion rates, lower math and language grades, and less long-term education in a study of over 1 million people in Denmark. (Journal of Neurology, Neurosurgery & Psychiatry)

In a phase I trial in China, 16 people with refractory autoimmune neurologic conditions, including seven progressive multiple sclerosis patients, had complete B-cell depletion and preliminary clinical improvement after lentiviral in vivo CD19 CAR T-cell therapy. (New England Journal of Medicine)

The FDA warned that Boston Scientific’s recalled spinal cord stimulator for chronic limb pain was linked to 1,081 serious injuries due to an issue involving its lead component.

Investigational delpacibart etedesiran did not meet its primary endpoint in the phase III HARBOR study of patients with myotonic dystrophy type 1, Novartis said.

Immigration status was associated with longer stays in the intensive care unit after ischemic stroke in Canada, according to retrospective data. (Neurology)

Experts offered suggestions for clinicians who need to speak with families about brain death evaluation and determination. (JAMA)