Piping Hot Drinks & Esophagus Cancer; Belching Disorder in GERD; Outbreak Sickens 22

People who consumed their hot beverages at a “very hot” temperature had a threefold higher risk for squamous cell carcinoma of the esophagus compared with those who drank them at a “warm” temperature, an analysis of two large U.K. cohorts suggested. (International Journal of Cancer)

High-penetrance colorectal cancer (CRC) predisposition germline variants were present in 5.4% of CRC patients and in 12.2% of the early-onset cases, according to a meta-analysis. (Lancet Gastroenterology & Hepatology)

Relapse following surgery for localized appendiceal adenocarcinoma was uncommon, and adjuvant chemotherapy was not associated with improved relapse-free or overall survival, a retrospective U.S. study found. (JAMA Surgery)

The American Gastroenterological Association updated its guidelines on the management of ampullary neoplasms. (Clinical Gastroenterology and Hepatology)

A multicenter study of gastroesophageal reflux disease (GERD) found excessive supragastric belching in 20% of patients and estimated that 25% of their acid exposure time could be attributed to the belching disorder. (Gut)

Spyre Therapeutics said a phase II study of its investigational anti-interleukin (IL)-23 drug for moderately-to-severely active ulcerative colitis met its primary and secondary endpoints.

Super-resolution contrast-enhanced ultrasound (CEUS) proved accurate for measuring Crohn’s disease activity through high-resolution depiction of microstructural changes and demonstrated better performance versus conventional CEUS, researchers reported in Radiology.

A meta-analysis of hidradenitis suppurativa studies cleared IL-17 inhibitors of inflammatory bowel disease risk. (JAMA Dermatology)

The FDA said it’s investigating a Salmonella ​outbreak linked to broccoli sprouts in four states — Washington, Montana, Idaho, and Utah — that has sickened 22 people and hospitalized two.

A review article in Current Opinion in Nephrology & Hypertension made the case for incorporating the liver into cardiovascular-kidney-metabolic syndrome.

Researchers showed that predicting the risk of hard outcomes in patients with metabolic dysfunction-associated steatotic liver disease can be personalized with a joint latent class model that relies on the dynamics of non-invasive tests. (Clinical Gastroenterology and Hepatology)

A small study of people with cirrhosis suggested the feasibility of a novel at-home device for critical flicker frequency testing to identify minimal hepatic encephalopathy. (Gastro Hep Advances)